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Clotrimazole and miconazole cream (0.5%) in a 1%-methoxydimidate cream (1%). All the participants received placebo. children underwent physical examination at baseline and end of week 1. In 1, serum concentrations for all drugs Ponstan 500mg capsule were measured at the beginning and end of week 1. At 1, the mean baseline plasma glucose levels were 9.3 ± 4.0 and 9.6 1.3 h. In other words, both miconazole and triazole cream improved glycemic control after 1 week, whereas no statistical differences were observed in baseline glycemic control among the participants. Thus, there was a correlation between blood glucose concentrations and treatment response in both miconazole and triazole cream groups in the 1%-methoxydimidate group. Discussion This study showed that both miconazole and triazole cream could improve the glycemic control of children suffering from hyperglycemia, after 1 week of treatment. It is surprising that miconazole cream can improve blood glucose control when it was associated with a significantly lower serum concentrations of drug in the 1%-methoxydimidate cream group than with that in the placebo group. Viagra generic online cheapest It seems that miconazole cream can help prevent hyperglycemia, because it significantly reduced blood glucose concentrations in children with hyperglycemia. The use of miconazole cream improves the glycemic control of hyperglycemic children only after 1 week of miconazole cream treatment. The fact that miconazole cream seems to slow the decline of serum glucose concentration after 1 week of treatment suggests that miconazole cream reduces metabolic rate to some extent but is capable of protecting against hyperglycemia in some patients suffering from severe hyperglycemia. In addition, this is a case of therapeutic benefit miconazole cream in reducing hyperglycemia with minimal toxic effects. This finding is also supported by the finding that miconazole cream significantly decreases serum glucose concentration and lowers blood pressure in children suffering from elevated plasma glucose level [19]. Thus, it seemed that the protective, therapeutic effect miconazole cream had on the glycemic changes could be attributed to its ability lower serum levels of both drugs and the improvement in blood glucose concentrations. In the previous studies, concentration of miconazol was higher than placebo [23, 24], but the improvement in glucose levels of the children had been small, because the miconazole therapy did not reduce plasma glucose concentrations to significant degree [5]. It seems that the concentration of miconazol (0.25%) in the triazole cream was low enough to cause a significant improvement in glycemic control. It is unlikely that miconazole concentration was reduced substantially at concentrations >0.5%, because triazole cream contains several active ingredients including the ingredient quinazoline hydrochloride [25]. addition of a different ingredient, but in the lower concentration of 0.25% (miconazole or quinazoline), seems to reduce the effect of miconazol on a similar basis. In addition, generic brand of flagyl although the concentration of miconazol in quinazoline cream was low, the effect on glycemic control was much larger than in the 1%-methoxydimidate cream group, and it was also more efficient. Therefore, it is reasonable to assume that the dose of miconazol in quinazoline cream must be lower than the dosage proposed in this study. Moreover, the dose of miconazol in this flagyl farmaco generico study was accordance with the published results [26, 27], whereas higher miconazol dose was reported in other studies [6]. Consequently, it was concluded that miconazole concentration in the quinazoline cream might be slightly higher than in the 1%-methoxydimidate cream. In addition, the reduction of serum glucose concentrations caused by triazole cream in this study was similar to those seen in previous studies. studies, the dose of triazole cream in combination with other drugs was not sufficient to achieve therapeutic hypoglycemia [3], because treatment of hyperglycemia started too high (1–2 kg in some studies) combination with other antihyperglycemic medicine, such as lizumab, nifedipine, and glyburide, because these drugs reduce blood glucose concentration only when combined. In the present study, dose of triazole cream was significantly lower than that in previous studies (at least 1.2 g/d in the present study). Furthermore, treatment of hyperglycemia started very low (5–10 kg) with the 1%-methoxydimidate cream group (Fig. 2). This result supports the contention that dose of triazole cream in the 1%-methoxydimidate group was sufficient for therapeutic hypoglycemia.

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